Banner Congress EUSAAT 2012

Final Programme

(For the ABSTRACTS please click HERE! The abstracts of this European Congress will be published in the scientific journal ATLA — Alternatives to Laboratory Animals.)

 

 

 Tuesday, 04.09.2012

13:00-18:00

 

Pre-congress meeting
Meeting of Austrian regulators responsible for approving animal experiments – part I
(invited participants only)

 Wednesday, 05.09.2012

10:00-18:00

 

Registration open

09:00-12:00

 

Pre-congress meeting
Meeting of Austrian regulators responsible for approving animal experiments – part II
(invited participants only)

14:00-18:00

 

Pre-congress meeting
ETS-EUSAAT joint afternoon symposium

Innovations and applications of the embryonic stem cell test (EST)

13:00-17:00

 

Installation of exhibition

13:00-17:00

 

Poster area accessible

19:00

 

Welcome reception – get together (at the congress venue)

 Thursday, 06.09.2012

07:30-09:00

 

Registration

09:00-09:10

 

Welcome Addresses

sponsor
Banner SkinEthic laboratories

 Session I: Progress in 3Rs research - EU FP6 & FP7 projects
 Chairs: Troy Seidle (CA) & Gerhard Gstraunthaler (AT)

09:10-09:30

 

Horst Spielmann, FU Berlin, DE-Berlin
The EU FP7 project AXLR8: drafting a roadmap to innovative toxicity testing in the 21st century (“Tox21”) in Europe and the USA

09:30-09:50

 

Michael Schwarz, University of Tübingen, DE-Tübingen
Towards the replacement of in vivo repeated-dose systemic toxicity: The SEURAT-1 research initiative

09:50-10:10

 

Paul Jennings, Innsbruck Medical University, AT-Innsbruck
The Predict-IV project: Integrating “omic” data and pharmacokinetic modelling

10:10-10:40

 

Coffee break and posters


VITROCELL Systems GmbH

 Session II: Chemicals - REACH and animal welfare
 Chairs: Susanna Louhimies (BE) & Robert Landsiedel (DE)

10:40-10:55

 

Katy Taylor, BUAV/ECEAE, UK-London
The first REACH deadline: experience with the testing proposals system to reduce animal testing

10:55-11:10

 

Alistair Currie, PETA, UK-London
When is animal testing a last resort under REACH?

11:10-11:30

 

Ursula G. Sauer, Scientific Consultancy – Animal Welfare, DE-Neubiberg
Using the Go3R search engine to collect toxicological data and 3Rs relevant information for REACH registration dossiers
(please click HERE for the presentation as PDF)

11:30-11:50

 

Susanne N. Kolle, BASF SE, DE-Ludwigshafen
Putting the parts together: Combining in vitro methods to test for skin sensitizing potential

11:50-12:05

 

Costanza Rovida, CAAT-Europe at the University of Konstanz, DE-Konstanz
Considerations about how the reproductive toxicity has been managed in the REACH registration dossiers. What will happen in the future?
(please click HERE for the presentation as PDF)

12:05-12:20

 

Albrecht Poth, Harlan Cytotest Cell Research GmbH, DE-Rossdorf
The use of the she cell transformation assay in hazard and risk assessment for industrial chemicals under REACH
(please click HERE for the presentation as PDF)

12:20-13:30

 

Lunchtime poster session (business lunch to be served at the congress venue)


sponsor

Logo BASF

BASF uses alternative methods in toxicological testing wherever it is possible and scientifically sound.  For the last two decades, BASF has been developing and validating alternative methods to further their use and regulatory acceptance. Recent developments include the skin sensitization in vitro test strategy and MetaMap®Tox Profiler to detect toxicological modes of action.


 Session III: 7th Amendment of the EU Cosmetics Directive
 Chairs: Eleonore Haltner-Ukomadu (DE) & Dagmar Jirova (CZ)

13:30-13:45

 

Irmela Ruhdel, Animal Welfare Academy, DE-Neubiberg
Meeting the Deadline 2013 - the Animal Welfare Perspective
(please click HERE for the presentation as PDF)

13:45-14:00

 

Marlous Kooijman, Utrecht University, NL-Utrecht
Understanding the lengthy process to replace the Draize test
(please click HERE for the presentation as PDF)

14.00-14.15

 

Udo Bock, Across Barriers GmbH, DE-Saarbrücken
Characterization of a human cornea construct for a rapid screening of preservatives and evaluation of their effect during permeability assays to reduce animal testing

14:15-14:30

 

Günter Weindl, FU Berlin, DE-Berlin
Esterase activity in excised and reconstructed human skin - biotransformation of prednicarbate and the model dye fluorescein diacetat

14:30-15:00

 

Coffee break and posters


Logo Primacyt

 Session IV: Directive 2010/63/EU and other legal and ethical topics
 Chairs: Ursula G. Sauer (DE) & Norbert Alzmann (AT)

15:00-15:30

 

Susanna Louhimies, The European Commission, BE-Brussels
Working together towards successful transposition
(please click HERE for the presentation as PDF)

15:30-15:45

 

Kirsty Reid, EWLA/Eurogroup for Animals, BE-Brussels
Requirement for a comprehensive EU strategy to decrease animal testing

15:45-16:00

 

Norbert Alzmann, Messerli Research Institute, AT-Vienna
Responsibility in animal experimentation. Assistance for the harm-benefit analysis in the context of the new EU Directive

16:00-16:15

 

Roman Kolar, Animal Welfare Academy, DE-Neubiberg
Transposition of Directive 2010/63/EU: Missed opportunities in Germany
(please click HERE for the presentation as PDF)

16:15-16:30

 

Kristina Wagner, Animal Welfare Academy, DE-Neubiberg
Inconsistencies in data requirements of EU legislation involving tests on animals
(please click HERE for the presentation as PDF)

 Round table
 The new Directive and the validation procedure: unsurpassable hurdles to 3Rs method acceptance?
 Moderation: Ursula G. Sauer (DE)

16:30-17:00

 

Keynote lecture
Manfred Liebsch, ZEBET at the BfR, DE-Berlin
Development and validation of alternative approaches according to article 47 of Directive 2010/63/EU: validation at stake?

17:00-18:00

 

Round table
Moderation: Ursula G. Sauer (DE)
Participants confirmed: Susanna Louhimies (BE-Brussels), Helena Kandarova (SK-Bratislava), Dagmar Jírová (CZ-Praha), Robert Landsiedel (DE-Ludwigshafen), Coenraad Hendriksen (NL-Utrecht), Manfred Liebsch (DE-Berlin), Horst Spielmann (DE-Berlin)

18:00-19:00

 

Poster session I with coffee
Survey of the posters in presence of the authors

19:10-20:15

 

Annual general assembly of EUSAAT (for the invitation as pdf-file click HERE)

sponsor
Logo Across Barriers

 Friday, 07.09.2012

 Session V: 3Rs progress in other sectors
 Chairs: Heike Behrensdorf-Nicol (DE) & Roman Kolar (DE)

09:00-09:30

 

Coenraad Hendriksen, Netherlands Vaccine Institute, NL-Bilthoven
The consistency approach in lot release testing of vaccines

09:30-09:45

 

Stefan Vaessen, University of Applied Sciences Utrecht, NL-Utrecht
Potential of pertussis toxin sensitive genes in human dendritic cells to evaluate safety of pertussis vaccines

09:45-10:00

 

Heike Behrensdorf-Nicol, Paul-Ehrlich-Institut, DE-Langen
A combined in vitro assay taking into account binding and enzymatic activity allows sensitive detection of active tetanus neurotoxin in vaccines

10:00-10:15

 

Tzutzuy Ramirez Hernandez, BASF SE, DE-Ludwigshafen
A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids
(please click HERE for the presentation as PDF)

10:15-10:30

 

Troy Seidle, Humane Society International, CA-Toronto
3R innovations and best practices in European pesticide regulation
(please click HERE for the presentation as PDF)

10:30-10:45

 

Susanne N. Kolle, BASF SE, DE-Ludwigshafen
Predicting eye irritation of agrochemical formulations according to different classification schemes by in vitro methods

10:45-11:00

 

Peter van Meer, Utrecht Institute for Pharmaceutical Sciences, NL-Utrecht
The future of non-human primates in the development of biopharmaceuticals
(please click HERE for the presentation as PDF)

11:00-11:30

 

Coffee break and posters


Banner Hyglos - EndoLISA - The new non Animal Method for Endotoxin Detection

 Session VI: Inhalation & nanotoxicology
 Chairs: Helena Kandarova (SK) & Manfred Liebsch (DE)

11:30-11:50

 

Anna Kühn, Helmholtz-Institute for Pharmaceutical Research Saarland, DE-Saarbrücken
Immortalization of primary human alveolar epithelial cells: Development of a new in vitro model of the air-blood barrier

11:50-12:05

 

Christine Pohl, University Medical Centre, DE-Mainz
A triple culture model to study inhalation toxicology

12:05-12:20

 

Lan Lauenstein, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, DE-Hannover
Pre-validation of the ex vivo model PCLS for the prediction of respiratory toxicology

12:20-12:35

 

Silvia Letasiova, MatTek In Vitro Life Science Laboratories, SK-Bratislava
Use of normal human 3-dimensional (NHu-3D) tissue models (EpiDerm, EpiAirway) for nanotoxicology applications
(please click HERE for the presentation as PDF)

12:35-12:50

 

Olga Shpigelman, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, DE-Hannover
Cell and tissue culture models for the assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles

12:50-13:05

 

Martha Liley, CSEM SA, CH-Neuchâtel
New devices for model biological barriers in nanotoxicology, nanomedicine and inhalation studies

13:05-13:20

 

Julia Susewind, Saarland University, DE-Saarbrücken
An inflamed and non-inflamed triple culture model of the intestinal mucosa to assess the cytotoxicity of engineered nanoparticles

13:20-14:30

 

Lunchtime poster session (business lunch to be served at the congress venue)

 Session VII: 3R goes 3D - implementation of 3D methods in toxicity testing
 Chairs: Ellen Fritsche (DE) & Catherine Willet (USA)

14:30-14:55

 

Ellen Fritsche, Leibniz Research Institute of Environmental Medicine, DE-Düsseldorf
In vitro assessment of developmental neurotoxicity using 3D cultures: species can make a difference

14:55-15:15

 

Mark Rosowski, TU Berlin, DE-Berlin
“Human-on–a-chip” concepts to implement in vitro repeated-dose substance toxicity testing predictive to human exposure
(please click HERE for the presentation as PDF)

15:15-15:35

 

Dmitry Sakharov, Institute of Pathology and Pathophysiology, RU-Moscow
The Russian “human-on-a-chip” program for animal-free substance evaluation
(please click HERE for the presentation as PDF)

15:35-15:50

 

Tuula Heinonen, University of Tampere, FI-Tampere
3D-cardiovascular construct to mimic properties of native heart tissue for safety and efficacy testing of chemical substances

15:50-16:05

 

Jens Hoffmann, CellSystems Biotechnologie Vertrieb GmbH, DE-Troisdorf
The reconstructed epidermis EST1000 allows sub-classification of corrosive chemicals in vitro

16:05-16:20

 

Helena Kandarova, MatTek In Vitro Life Science Laboratories, SK-Bratislava
Modern approaches to assessing the phototoxicity (photoirritation) potential of substances and formulations using a tiered testing strategy combining analytical and in vitro test systems

16:20-16:50

 

Coffee break and posters

 Session VIII: Free communications
 Chairs: Tzutzuy Ramirez Hernandez (DE) & Klaus Schröder (AT)

16:50-17:05

 

Tanja Waldmann, University of Konstanz, DE-Konstanz
Use of a human embryonic stem cell-based test system for neurodevelopmental toxicity testing and epigenetic profiling

17:05-17:20

 

Stefan Fennrich, Universitätsklinikum Tübingen, DE-Tübingen
Investigating the interaction of pyrogenic contaminations with medical devices using a human specific in vitro assay
(please click HERE for the presentation as PDF)

17:20-17:35

 

Günther Weindl, FU Berlin, DE-Berlin
Characterization of reconstructed human skin following topical treatment with glucocorticoid creams

17:35-17:50

 

Karin Schütze, Celltool GmbH, DE-Tutzing
Micro-Raman Spectroscopy – an alternative tool for the non-invasive analysis of cellular states and identification

17:50-19:00

 

Poster session II with coffee
Survey of the posters in presence of the authors

19:30

 

Departure for the social evening

20:00

 

Social evening

Royal Guitar Club - Kings of Acoustic Music

 Saturday, 08.09.2012

 Session IXa:  21st century non-animal tools for basic and biomedical research
 Chairs: Constanza Rovida (DE) & Horst Spielmann (DE)

09:00-09:25

 

Nina Hasiwa, CAAT-Europe at the University of Konstanz, DE-Konstanz
A possible roadmap for animal-free systemic toxicity testing
(please click HERE for the presentation as PDF)

09:25-09:50

 

Catherine Willett, The Humane Society of the United States, USA-Gaithersburg
The role of adverse outcome pathways in streamlining hazard and risk assessment
(please click HERE for the presentation as PDF)

09:50-10:05

 

Johannes Grillari, Vienna Institute of BioTechnology, AT-Vienna
Immortalization of urine-derived renal proximal tubular epithelial cells: A non-invasive cell source for relevant and standardizable kidney toxicity testing and generation of induced pluripotent stem cells

10:05-10:20

 

Bastian Zimmer, Doerenkamp-Zbinden Chair of in Vitro Toxicology and Biomedicine, DE-Konstanz
Evaluation of developmental toxicants and signalling pathways in a functional test based on the migration of human neural crest cells

10:20-11:00

 

Coffee break and posters

 Session IXb: 21st century non-animal tools for basic and biomedical research
 Chairs: Tuula Heinonen (SF) & Katy Taylor (UK)

11:00-11:15

 

Robin Williams, Royal Holloway University of London, UK-Egham
Development of a first-choice non-animal model for bipolar disorder research
(please click HERE for the presentation as PDF)

11:15-11:30

 

Mark Cunningham, Newcastle University, UK-Newcastle upon Tyne
From neuronal activity to brain dynamics: novel insights into epilepsy from human in vitro studies

11:30-11:45

 

Jakob Bonne Larsen, CSEM SA, CH-Landquart
Microsensors for monitoring the functions of liver cells in a modular based microfluidic polymer system

11:45-12:00

 

Olivier Guenat, University of Bern, CH-Bern
Advanced microfluidic-based in vitro models for lung research
(please click HERE for the presentation as PDF)

12:00-12:15

 

Joachim Wiest, cellasys GmbH, DE-Munich
BioChip-based electrochemical platform for the label-free monitoring of living cells
(please click HERE for the presentation as PDF)

12:15

 

Closing remarks
End of the congress

congress supported by

Banner suonix group GmbH

 

 

 

(For the ABSTRACTS please click HERE! The abstracts of this European Congress will be published in the scientific journal ATLA — Alternatives to Laboratory Animals.)