Posters: click hereAbstracts of lectures and posters: click here(pdf, 1,77 MB; all which were submitted in time; published in Altex 27, Suppl. 2/10)
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Wednesday, September 1st 2010 |
12:00-19:00
| Registration open |
| 14:00-19:00 | Pre-Congress Meetings |
| | AXLR8 - '21st Century Approaches to Toxicology'
Public Information Forum (http://axlr8.eu/workshops/) |
| | funded by the EU FP6 & FP7 program on “Alternative Testing Strategies” |
| 14:00-14:05 | Welcome & Opening Remarks
Chairperson (Troy Seidle, Humane Society International, UK)
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| 14:05-14:30 | Horst Spielmann, Freie Universität Berlin, DE
The EU FP7 Project "AXLR8" |
14:30-15:00
| Carl-Frederik Mandenius, Linköping University, SE
The EU FP6 Project "VITROCELLOMICS"
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15:00-15:30
| Erwin Roggen, Novozymes, DK
EU FP6 Project Sens-it-iv |
15:30-15:45
| Coffee break
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15:45-16:15
| Walter Pfaller, Innsbruck Medical University, AT
The EU FP7 Project "PREDICT-IV" |
16:15-16:45
| Imran Shah, Environmental Protection Agency, US
The US ToxCast & Tox21 Programs |
16:45-17:30
| Panel Discussion
Chairperson (Greet Schoeters, VITO-CARDAM, BE) |
17:30
| Close
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| | This event is free to attend, but pre-registration is encouraged.
Register online at AXLR8.eu/workshops.
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| | Workshop - Presentation of search engines with hands-on trials on PC terminals |
14:00-14:45
| Daniel Brunner, Linz, A
The online database for serum-free cell culture media
GROUP A |
| 15:00-15:45 | Daniel Brunner, Linz, A
The online database for serum-free cell culture media
GROUP B
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| 16:00-17:20 | Barbara Grune, BfR, Berlin, D, Ursula G. Sauer, Scientific Consultancy - Animal Welfare, Neubiberg, D, Liliana Barrio-Alvers, Transinsight GmbH, Dresden, D
The Go3R Search Engine
GROUP C |
| 17:30-18:50 | Barbara Grune, BfR, Berlin, D, Ursula G. Sauer, Scientific Consultancy - Animal Welfare, Neubiberg, D, Liliana Barrio-Alvers, Transinsight GmbH, Dresden, D
The Go3R Search Engine
GROUP D
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| | This workshop is free to attend, but pre-registration is required.
Each group is limited up to 18 participants. |
|
| 16:00-18:00 | Pre-Congress Symposium on Serum-free Cell Culture
Follow-up of the Copenhagen Workshop 2009 |
| | Chairs: Gerhard Gstraunthaler, A, and Jan Van der Valk, NL |
| | Agenda 1. Workshop Report (Toxicol. in Vitro 2010):
Responses, Discussion
2. Follow-up:
a. Serum-free cell culture - what has been achieved?
b. Problems, open questions - common grant application?
c. Quality of FBS batches, experiences with FBS lots |
| | This symposium is free to attend, but pre-registration is required. Please register via email:
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
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13:00-17:00
| Build-up of exhibition |
13:00-17:00
| Poster area accessible |
19:00-22:00
| Welcome Evening - Get Together |
| 19:00-19:30 | Opening Lecture
Walter Pfaller, Innsbruck Medical University, A
Lessons learned from 25 years of nephrotoxicity testing in vitro |
19:30-22:00
| Get Together Party
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Thursday, September 2nd 2010 |
07:30-09:00
| Registration |
09:00-09:15
| Welcome Addresses |
| | Session I - Legal, Ethical and Policy Topics Regarding Alternatives |
| | Chairs: Emily McIvor, UK, and Alois Haslinger, A |
09:15-09:45
| State of the art lecture
Susanna Louhimies, EU - DG Environment, B
Current status of the revision process regarding the Directive 609/86 EEC
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| | oral presentations
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09:45-10:00
| Irmela Ruhdel, D
New EU Directive on the protection of laboratory animals: animal welfare perspective |
10:00-10:15
| Kristie Sullivan, USA
A qualitative and quantitative examination of the impact of chemical regulation legislation on the field of toxicity testing |
10:15-10:30
| Hans Steinkellner, I
Human Health Risk Assessment of Pesticides - Novel Approaches explored by EFSA’s PPR Panel |
10:30-10:45
| Dagmar Jirova, CZ
Alternative methods as an integral part of in-market control on cosmetics in the Czech Republic |
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10:45-11:15
| Coffee break and posters
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| | Session II - Metabolism and Toxicokinetics |
| | Chairs: Katrin Zeilinger, D, and Mathieu Vinken, B
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11:15-11:45
| State of the art lecture
Mia Emgard, Cellartis AB, S
Human pluripotent stem cells and their derivatives in assay for chemical risk assessment
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| | oral presentations
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| 11:45-12:00 | Katrin Zeilinger, D
Human liver cell cultivation in a miniaturized 3D bioreactor system for in vitro studies on hepatic drug toxicity
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12:00-12:15
| Jean-Paul Derouette, CH
An in vivo like expression pattern of CYP450 enzymes found in a 3D in vitro model of the human airway epithelium - MucilAir™ |
12:15-12:30
| Jennifer Bolleyn, B
Effect of Trichostatin A on miR-122 expression in primary hepatocyte cultures
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12:30-12:45
| Anett Ullrich, D
Human hepatocyte cultures allow repeated application of drugs resulting in repeatable effects on hepatocellular metabolism |
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12:45-14:00
| Lunch (business lunch to be served at the congress venue)
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13:00-14:00
| Business Lunch - ESTIV Students Session
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| | Chair: Maria Laura Scarino, I |
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| | Session III - Skin / Sensitisation and Eye Irritation |
| | Chairs: Nathalie Alépée, F, and Chantra Eskes, NL
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14:00-14:30
| State of the art lecture
Patrick Amcoff, OECD, F
Skin toxicity and regulations aspects
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| | oral presentations
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14:30-14:45
| Stefanie Schoepe, D
Identification of novel in vitro test systems for the determination of glucocorticoid receptor-ligand induced skin atrophy
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14:45-15:00
| Guenther Weindl, D
Models of localized Candida infections based on in vitro reconstituted human epithelia
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15:00-15:15
| Marisa Meloni, I
In vitro safety assessment of cosmetic products: investigation of new endpoints for eye irritation
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15:15-15:30
| Sebastian Hoffmann, D
ECVAM prevalidation study on skin sensitisation alternatives: update on progress
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15:30-15:45
| Nathalie Lambrechts, B
Assessment of chemical skin sensitizing potency by an in vitro assay based on human dendritic cells
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15:45-16:00
| Andreas Natsch, D
Prediction of skin sensitizers by combining a high-throughput keratinocyte-based reporter gene assay with peptide reactivity measurements
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16:00-16:15
| Silvia Martinozzi Teissier, F
Development, refinement and combination of in vitro assays to hurdle skin sensitization complexity
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| | Session IV - Good Cell Culture Practice |
| | Chair: Gerhard Gstraunthaler, A, and Rodger Curren, USA
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16:15-16:45
| State of the art lecture
Wilhelm Dirks, DSMZ, D
STR DNA Typing: Intra- and Interspecies Cross-Contamination Detection of Human Cell Lines
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16:45-17:00
| Jan van der Valk, NL
Improving in vitro methods by developing and using defined culture media |
17:00-17:15
| Sabrina Ehnert, D
Use of autologous serum improves yield and quality of neohepatocytes for in vitro toxicity testing |
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17:15-19:00
| Poster session I |
| | with coffee & regarding topics of session I to IV
survey of the posters with presence of the authors
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| | Chairs: M. Liebsch, D, Pilar Prieto, I, Irmela Ruhdel, D, Paul Jennings, A, Jan Van der Valk, NL
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| | list of posters (or as pdf: in alphabetical order (pdf, 242 KB) or sorted by session-numbers (pdf, 238 KB)) |
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19:30-20:00
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Friday, September 3rd 2010 |
| | Session V - Acute and Long Term Toxicity - part A |
| | Chairs: Greet Schoeters, B, and Dagmar Jirova, CZ
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08:30-09:00
| State of the art lecture
Paul Jennings, Innsbruck Medical University, A
The role of the Nrf2 pathway in nephrotoxicity
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09:00-09:15
| Hasso Seibert, D
Peroxide-induced oxidative stress and cell death in C6 astroglioma cells
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09:15-09:30
| Samuel Constant, CH
Assessment of acute, long term and chronic respiratory toxicity using a long shelf life 3D model of the human airway epithelium
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09:30-09:45
| Ralph Pirow, D
Testing of the toxicity of volatile compounds on human lung cells using the Air/Liquid Interface (ALI) culturing and exposure technique: a prevalidation study
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09:45-10:00
| Annette Kopp-Schneider, D
Statistical Analysis of the AcuteTox data aimed to identify an in vitro testing strategy for prediction of acute oral toxicity
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10:00-10:30
| Coffee break and posters
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| | Session VI - Acute and Long Term Toxicity - part B |
| | Chairs: Eva-Maria Collnot, D, and Klaus R. Schröder, A
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| | oral presentations
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10:30-10:45
| Seyoum Ayehunie, USA
EpiVaginal tissue model for preclinical toxicity screening of chemicals/formulations following single or repeat applications
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10:45-11:00
| Sara Lindén, S
In vitro gastrointestinal mucosal surfaces for studying host-pathogen interactions at the mucosal interphase
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11:00-11:15
| Anja Wilmes, A
Transcriptomic, proteomic and metabolomic alterations in RPTEC/TERT1 cells in response to Cyclosporine A |
11:15-11:30
| Albrecht Poth, D
In vitro cell transformation assays - Their use in safety and risk assessment |
| | |
| | Special Session on Antibody Production |
| | sponsored by the Dr Hadwen Trust (UK) |
| | Chair: Alison Gray, UK, Sebastien Farnaud,UK |
| | oral presentations
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11:30-11:45
| AS Kang, UK
Recombinant antibodies. Past, Present and Future
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11:45-12:00
| Dong Barraclouogh, UK
Exploitation of potential aptamer technology to replace animal antibody against human tumour biomarkers
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12:00-12:15
| Mingyue He, UK
Generation of antibodies in vitro: No living cells required
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12:15-12:30
| Discussion
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| 12:30-14:00 | Lunch (business lunch to be served at the congress venue)
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| | Session VII - Nanotoxicology |
| | This session is sponsored by Animalfree Research, CH-Zurich
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| | Welcome Address: Sabine Umbricht-Vonlanthen, Director Animalfree Research, CH-Zurich
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| | Chairs: Ursula G. Sauer, D, and Robert Landsiedel, D
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14:00-14:20
| State of the art lecture:
Robert Landsiedel, BASF, D
The use of alternative methods for toxicity testing of nanomaterials
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| | oral presentations
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14:20-14:35
| Mario Götz, D
The role of alternative test methods in nanotoxicology
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14:35-14:50
| Christina Brandenberger, CH
Air liquid exposure of gold nanoparticles to study effects, uptake and intracellular distribution in a human 3D epithelial airway model
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14:50-15:05
| Eva-Maria Collnot, D
In vitro model of inflammatory bowel disease for drug formulation testing and screening
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15:05-15:20
| Anne Kahru, EE
High-to-medium-throughput evaluation of the ecotoxicity and toxicological profiling of synthetic nanoparticles |
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15:20-16:00
| Round Table – Towards non-animal testing strategies in nano-toxicology – what needs to be done and who will do it?
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| | Chair and introductory note: Ursula G. Sauer, D
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| | Participants: Robert Landsiedel, D, Mario Götz, D, Christina Brandenberger, CH, Eva-Maria Collnot, D, Anne Kahru, EE, Cyrille Krul, NL, Eleonore Fröhlich, A
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| | Closing remarks of this session: Stefanie Schindler, Animalfree Research, CH
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16:00-18:00
| Postersession II |
| | with coffee & regarding topics of session V to IX
survey of the posters with presence of the authors
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| | Chairs: M. Liebsch, D, Pilar Prieto, I, Irmela Ruhdel, D, Paul Jennings, A, Jan Van der Valk, NL
|
| | list of posters (or as pdf: in alphabetical order (pdf, 242 KB) or sorted by session-numbers (pdf, 238 KB)) |
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17:30-18:30
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19:00
| Departure to the Social Evening |
19:30
| Social Evening - Award Ceremonies |
| | "Dieter Lütticken Award (DLA) To Stimulate Reduction Of Animal Testing"
awarded by the "Intervet Schering-Plough Animal Health Foundation"
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| | Award of the Doerenkamp-Zbinden Foundation |
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Saturday, September 4th 2010 |
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| | Session VIII - Reproductive Toxicology and Stem Cells |
| | Chairs: Horst Spielmann, D, Kristie Sullivan, US
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09:00-09:30
| State of the art lecture:
Horst Spielmann, FU Berlin, D
The way forward in reproductive/developmental toxicology
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| | oral presentations
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09:30-09:45
| Katrin Hayess, D
Mouse embryonic stem cells in developmental neurotoxicity testing: aiming at higher throughput and specificity |
09:45-10:00
| Pablo Steinberg, D
The coupling of a metabolic activation system (primary hepatocytes) to the murine embryonic stem cell test expans its use in reproductive toxicity testing
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10:00-10:15
| Gabriela G. Cezar, USA
Predicting Developmental Toxicity With Human Embryonic Stem Cells and Metabolomics |
10:15-10:30
| Sarah Snykers, B
Optimised 1D and 3D isolation and expansion of multipotent human adipose–derived stem cells
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10:30-11:00
| Coffee break and posters
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| | Session IX - New Developments and Novel Methods |
| | Chairs: Erwin Roggen, DK and Thomas Hartung, USA
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11:00-11:30
| State of the art lecture:
Thomas Hartung, CAAT, US
Lessons learned from alternative methods and their validation for a new toxicology in the 21st century
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| | oral presentations
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11:30-11:45
| Rodger Curren, USA
An in vitro ocular testing strategy for US EPA registration of anti-microbial cleaning products |
11:45-12:00
| Jacqueline Pusch, D
Establishment of a 3D intestinal tissue equivalent in vitro
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12:00-12:15
| Tine Hectors, B
Evaluation of in vitro models for investigation of endocrine disruptive effects on insulin metabolism using omics
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12:15-12:30
| Terry Riss, USA
Multiplexing Various In Vitro Toxicity Assays for High Throughput Screening
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12:30-12:45
| Kerstin Reisinger, D
The Hen´s egg micronucleustest (HET-MN): successful intra- and interlaboratory reproducibility study
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12:45-13:00
| Martin Leonard, IRL
Toxicity Profiling of Nephrotoxins in the Human Proximal Tubular RPTEC-TERT1 Cell Line: Influence of Hypoxia
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13:00-13:15
| Stefan Schildknecht, D
Application of human dopaminergic neurons for toxicity testing
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13:15-13:45
| Award Ceremonies |
| | Poster awards by ALTEX, EUSAAT and ESTIV
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13:45-14:00
| Concluding Remarks |
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14:00
| End of the Congress |
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| | Farewell sandwiches, coffee & tea |
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Additional information for all speakers: Please find here the guidelines for submitting manuscripts for the ESTIV/EUSAAT 2010 proceedings, to be published in Toxicology in Vitro - download pdf (75 KB) |
